Table 1: Validation scheme for an 8 days validation of the total-Ti and particle-TiO2 determination in human tissue (liver and spleen) based on duplicate analysis.

Laboratory Sample Performance Characteristic Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7 Day 8
Sample 1 (liver) repeatability/reproducibility xx x
Sample 2 (spleen) repeatability/reproducibility x xx
Sample 3 (liver) repeatability/reproducibility xx x
Sample 4 (spleen) repeatability/reproducibility x xx
Sample 5 (liver) repeatability/reproducibility xx x
Sample 6 (spleen) repeatability/reproducibility x xx
Sample 7 (liver) repeatability/reproducibility xx x
Sample 8 (spleen) repeatability/reproducibility x xx
Laboratory sample lose to detection limit detection limit x x x x x x x x
Matrix matched trueness x x x x x x x x
Sample blanks selectivity x x x x x x x x
Sample under deiviating circumstances robustness xx

X: Single measurement; xx: Double measurement under repeatable conditions.