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Case Presentation 

Do Not Overlook Zona Herpes Ophthalmicus in a Patient Presenting with Pupil-Sparing Oculomotor Nerve Palsy

Mehtap Kocaturk, Mustafa Aksoy and Ozcan Kocaturk

Abstract

Herpes Zoster (HZ), relatively common syndrome, is the result of reactivation of Varicella-Zoster Virus (VZV) that lying in the ganglion after a prior bout of varicella. Reactivation is usually caused by a decline in the specific cell-mediated immunity to VZV with aging, immunosuppression, trauma, and psychological stress.

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RESEARCH ARTICLE 

Evaluation of Sequential Organ Failure Assessment (SOFA) Performance in Neurocritical Care Patients Overtime: A Retrospective Cohort Study

Mariana Rabelo de Brito, Alexandre Guimarães de Almeida Barros, Lenise Valler, Fabricio Buchdid Cardoso, Ana Paula Devite Cardoso Gasparotto, Luciana Tiziani Silva, Cristina Bueno Terzi Coelho, Desanka Dragosavac and Antônio Eiras Falcão

Abstract

Prediction models are widespread used as surrogate markers of disease severity, benchmarking and resource allocation in critical care. After derivation, they should pass through validation in different settings before their general use in other populations.

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SHORT COMMUNICATION 

The History of Cerebrospinal Fluid Analysis in Multiple Sclerosis: A Great Development over the Last Centuries

Vecchio Domizia

Abstract

Cerebrospinal Fluid (CSF) analysis acquired a great role in the 1990's when applied to Multiple Sclerosis (MS) diagnostic work-up. The "watery fluid" by Andreas Vesalius remained unstudied till the introduction of Lumbar Puncture (LP) at the eighteenth century.

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Research Article 

Effect of Chinese Herbal Medicine Xixin Decoction on Aβ42 and its Regulatory Enzymes in APP/PS1 Double Transgenic Murine Brain

Diwu Yong-chang, Gu Zan, Cui Na, Yang Ke, Gu Jie, Zeng Jian, Li Xiang, Gao Yan-bin, Tang Xue-cheng and Zhai Jia-ming

Abstract

To observe the effect of a Xixin decoction on learning and memory in APP/PS1 transgenic mice in addition to hippocampal ultrastructure and hippocampal Aβ42 related regulatory enzymes.

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Review Article 

Advances for the Pharmacotherapy of Parkinson's Disease: Pharmacological Handling of the Ca2+/cAMP Signalling Interaction

Leandro Bueno Bergantin and Afonso Caricati-Neto

Abstract

Reduction of dopamine release from striatal dopaminergic neurons due to neuronal death is the main accepted concept of Parkinson's disease. Parkinson's disease begins years before a clinical diagnosis can be consistently made (asymptomatic/slightly symptomatic patients).

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Review Article 

Statins as an Adjuvant Therapy for Psychotic Disorders: Current Evidence with a Systematic Overview of Double-Blind Placebo-Controlled Trials

Tjardo S Postma, Lyliana G Nasib, Maya J L Schutte, Marc M Bohlken, Peter Martens, Erna van't Hag, Selene R T Veerman, Marieke J H Begemann and Iris E C Sommer

Abstract

Evidence is accumulating that inflammatory processes play a role in the pathophysiology of schizophrenia. This suggests that anti-inflammatory drugs might have beneficial effects in the treatment of schizophrenia patients. Statins have cholesterol independent effects on inflammation and oxidative stress and could potentially improve positive, negative and/or cognitive symptoms of schizophrenia.

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Research Article 

Perinatal Administration of Caffeine in Mice Affects the Spatial Memory and Motor Coordination Later in Adult Life

Alsayed A, Jamal M, Al Hoty N, Eqab S, Ahmadi N, Sameer M, Alathem A, Al Saqer M, Alsulami B and Kamal A

Abstract

Data emerging that maternal consumption of moderate amount of caffeine will affect the development of the fetus and later the cognitive function of the brain. The aim of this study was to determine the effect of caffeine administration in pregnant mice on the learning and memory and motor coordination of offspring's at one and a half months of age.

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Review Article 

The Discovery of the "Calcium Paradox" Due to Ca2+/Camp Interaction: Novel Adventures for the Pharmacotherapy of Neurological/Psychiatric Disorders

Leandro Bueno Bergantin and Afonso Caricati-Neto

Abstract

Our discovery of the involvement of the interaction between intracellular signalling pathways mediated by Ca2+ and cAMP (Ca2+/cAMP interaction) in the neurotransmission and neuroprotection has produced new avenues in the understanding of the cellular and molecular mechanisms involved in the pathogenesis of neurological and psychiatric disorders, such as Alzheimer's and Parkinson's diseases.

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