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Research Article 

A Novel Nutrient Mixture Induces Apoptosis in Human Ovarian and Cervical Cancer Cells

M Waheed Roomi, Bilwa Bhanap, Aleksandra Niedzwiecki and Matthias Rath

Abstract

Cervical cancer and ovarian cancer are the deadliest gynecological malignancies and are the fourth and fifth leading causes of death in women respectively. The 5-year survival rate of patients has dropped to 15-20% when these cancers metastasize to distant organs. A unique formulation of nutrients containing green tea extract, ascorbic acid, lysine and proline, has exhibited anticancer effects in various cancers. In our earlier in vivo studies, the nutrient mixture significantly, reduced tumor weight and tumor burden of ovarian and cervical cancers.

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Research Article 

Utility of P16 and Ki-67 Expression in Cervical Biopsy with Cervical Intraepithelial Neoplasia 2 to Predict Diagnosis in Subsequent Cervical Excision Specimen

Alan Marcus, Zhenglong Wang and Khushbakhat Mittal

Abstract

Treatment guidelines differ for young women with Cervical Intraepithelial Neoplasia (CIN) 2 lesions on biopsy depending on their desire for future pregnancy. Therefore, we investigated the utility of using P16 and Ki-67 immunohistochemical stains on cervical biopsies diagnosed with CIN 2 to determine the outcome on subsequent excisional specimens. The study included 22 patients, with a mean age of 34 years and an age range from 20 to 51 years. Positive staining for p16 was identified in 21/22 patients.

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Case Report 

Neoadjuvant Chemotherapy with Paclitaxel and Nedaplatin plus Radical Surgery in Cervical Cancer during Pregnancy: A Case Report and Review of the Literature

Fei Xu, Gang Chen, Ling Chen, Hai Yan Weng, Kunli Su, Xuefen Zhang, Yong Cheng, Dabao Wu and Ying Zhou

Abstract

A 36-year-old Han Chinese female with cervical cancer staged as IB1 at the gestational age of 30 + 3 weeks was referred to our department. The patient and the family refused to term pregnancy and wanted pregnancy-preserving management, she was treated by neoadjuvant chemotherapy with paclitaxel 230 mg plus nedaplatin 120 mg first, and caesarean section; radical hysterectomy and pelvic lymph node dissection were performed three weeks later. Based on the pathology report, the patient underwent further radiotherapy, and the neonate was healthy.

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