Clinical Diabetes and Research

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Case Report 

SGLT2 Inhibition May Precipitate Euglycemic DKA after Bariatric Surgery

Hassan Elasha, Ali Mekki Elsheikh, Wafic Wafa and Karim Meeran

Abstract

SGLT2 inhibitors (SGLT2Is) lower blood glucose through inhibition of glucose reabsorption in the proximal renal tubules via an insulin independent mechanism. They have a low risk of hypoglycaemia with additional benefits including weight loss, blood pressure reduction and cardiovascular protection [1]. Euglycaemic diabetic ketoacidosis (euDKA) is a rare complication of SGLT2Is observed in patients with both type 1 and type 2 diabetes and can be easily overlooked by medical care providers because of the absence of marked hyperglycaemia.

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Review Article 

Ethical Issues Attendant with the Current Pandemic of Diabetes

Wayne X Shandera

Abstract

The International Diabetes Foundation (IDF) estimates that 415 million of the 7 billion global inhabitants have diabetes and this number is estimated to surge to 642 million by 2040.

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Review Article 

Therapeutic Agents Targeting at AGE-RAGE Axis for the Treatment of Diabetes and Cardiovascular Disease: A Review of Clinical Evidence

Hong Sheng Cheng, So Ha Ton and Khalid Abdul Kadir

Abstract

Advanced Glycation End Products (AGEs), together with its receptor (RAGE) are known to play a predominant role in the onset of diabetic micro- and macrovascular diseases.

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Brief Report 

Glargine U300 Insulin as a Better Option than Degludec U100 to Treat a Congenital Generalized Lipodystrophy Patient

Josivan G Lima, Natalia N Lima, Ricardo LM Lima, Maria FP Baracho and Lucia HC Nobrega

Abstract

Berardinelli-Seip Congenital Lipodystrophy (BSCL) is a rare autosomal recessive syndrome characterized by a generalized lack of adipose tissue, evolving with diabetes mellitus, dyslipidemia, and hepatic steatosis.

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Research Article 

Investigation of Pharmacological Responses to an Anti-Diabetic Drug Pioglitazone in Female Spontaneously Diabetic Torii (SDT) Fatty Rats, A New Obese Type 2 Diabetic Rat

Murai Y, Miyajima K, Shinohara M, Yamada T and Ohta T

Abstract

Rigorous glycemic control is essential to prevent the development of diabetes and onset of diabetic complications. Peroxisome proliferator-activated receptor (PPAR) γ activator pioglitazone is an anti-diabetic drug that exhibits glucose-lowering effects by enhancing insulin sensitivity in peripheral tissues.

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CASE REPORT 

Immune Response to Influenza Vaccination in Older Adults: Interactions with Type 2 Diabetes

Haleh Rokni, Nisha Nigil Haroon and Janet E McElhaney

Abstract

Type 2 diabetes mellitus (T2DM) is one of the most common disorders among adults over age 65. Both humoral and cellular immune responses are negatively affected by diabetes. Therefore infections such as influenza occur commonly with serious consequences in older individuals with T2DM. On the other hand aging is associated with changes in the immune system which result in disorders like T2DM and cardiovascular diseases.

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RESEARCH ARTICLE 

Fish Oil Intake during Pregnancy and Lactation in Rats Has Different Long-Term Effects on Glucose-Insulin Relationships in Male Pups Depending on Their Age

Lopez Soldado I, Ortega Senovilla H and Herrera E

Abstract

During pregnancy, polyunsaturated fatty acids are essential for fetal development. The fetus is unable to synthesize them and they have to come from the mother. Fish oil supplements (rich in docosahexaenoic acid) are often recommended during the perinatal stage and may contribute to programming future events.

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