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Research Article 

Artemisinin-dipeptidyl Vinyl Sulfone Hybrid Inhibitors of Plasmodium Falciparum Falcipain 2 with Favorable Pharmacokinetic Profile

Aubin N'Guessan, Eugene Megnassan, Nahosse Ziao, Vladimir Frecer, Yao Thomas N'Guessan and Stanislav Miertus

Abstract

In this work, we virtually design Artemisinin-Vinyl Sulfone Hybrid (AVSH) inhibitors of Falcipain2 (FP2) through Structure-Based Drug Design (SBDD) approach. From a series of 6 AVSH with known FP2 inhibitory activity, FP2-AVSHx complexes were built by in situ modification of the X-rays crystal structure of FP2 complexed with epoxysuccinate E64 (3BPF.pdb).

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Review Article 

Androgen Signaling: Promising Target for Prospective Cancer Therapy

Meenakshi Bandyopadhyay and Pushpanathan Muthuirulan

Abstract

Androgen is a steroid hormone that triggers or controls the development and maintenance of male sexual characteristics through their association with nuclear transcription factor known as Androgen Receptor (AR).

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