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Clinical Image 

An Uncommon Cause of a Refractory Gastric Ulcer

Jiten P Kothadia, Wuttiporn Manatsathit and Virkam Jala

Abstract

A 29-year-old female with a history of bipolar disorder presented to the emergency department (ED) with worsening epigastric pain. Two years ago, esophagogastroduodenoscopy (EGD) showed a 1.5-cm benign-appearing superficial ulcer in the pylorus. She was presumed to have an NSAID-induced peptic ulcer and was treated with proton pump inhibitor therapy. She had multiple hospitalizations for abdominal pain and several subsequent EGDs showing refractory gastric ulcer.

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Original Article 

Prognostic Value of Probe-Based Confocal Laser Endomicroscopy in Pediatric Inflammatory Bowel Diseases

Deenaz Zaidi, Hien Q Huynh, Matthew W Carroll and Eytan Wine

Abstract

The incidence of inflammatory bowel diseases (IBD), including Crohn disease (CD) and ulcerative colitis (UC), is increasing in children. We recently demonstrated increased epithelial gaps in the non-inflamed duodenum of CD and UC patients, and high capillary flow rates in the duodenum of UC patients using probe-based confocal laser endomicroscopy (pCLE). The aim of the present study was to determine if increased epithelial gap density or capillary flow could predict the clinical course of IBD patients and response to therapy.

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Case Report 

Pill-Induced Esophagitis with Mucosal Dissection: A Case Report

Marcelia Brandelli Vieira dos Santos, Fernanda de Quadros Onofrio and Jeronimo Conto de Oliveira

Abstract

Pill-induced esophageal injury was first described in 1970. It occurs when a caustic medicinal pill dissolves in the esophagus and releases its noxious content, particularly if transit is delayed. Injury of this type, called pill esophagitis or pill induced esophageal injury is common but unfortunately is under-reported.

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Original Article 

Factors Associated with Adverse Outcomes after Surgical Repair of Bile Duct Injury

Gustavo Martinez Mier, Juan Pablo Medina Granados, Horacio Enriquez De los Santos, Hector J Luna Ortiz, Nicolas Hernandez Herrera, Stefan Zilli Hernandez, Francisco A Lajud Barquin and Lhisty M Vazquez Ramirez

Abstract

Bile duct injury management requires skill of experienced surgeons at referral centers. Multiple factors may alter their outcomes.

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Case Report 

Hepatocellular Carcinoma Encountered during Laparoscopic Bariatric Surgery: Two Case Reports and Discussion

Pulimuttil James Zachariah, Wei Jei Lee and Kong-Han Ser

Abstract

Recent epidemiological data demonstrate a rise in the prevalence of Hepatocellular Carcinoma (HCC) and Non-Alcoholic Fatty Liver Disease (NAFLD) in obesity and diabetes.

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Original Research 

Helicobacter Pylori IgG Sero-Prevalence Study in Two Adjacent Regions of Contrasting Gastric Cancer Rates and Bracken Fern Frequency in Western Venezuela

Marisabel Avendano-Meza, Cesar I Perez-Maldonado and Miguel E Alonso-Amelot

Abstract

As Human Gastric Cancer Death Rates (HGCDR) is unevenly distributed in western Venezuela, we explored possible risk factors, among which Helicobacter Pylori (Hp) infection alongside bracken fern invasion could be differential contributors.

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Review Article 

Impact of Genetic Testing in the Diagnosis and Management of Sucrase-Isomaltase Deficiency

Lombardo Rachel C, Hopkin Robert and Abu-El-Haija Maisam

Abstract

The proband was of Arabic descent and evaluated for intractable diarrhea and poor growth. Molecular testing identified a nonsense mutation in the sucrase-isomaltase (SI) gene consistent with a diagnosis of sucrase-isomaltase deficiency (CSID).

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Prospective 

Colitis from an Artist's Prospective

Jamie E Ehrenpreis, Rachel Harper, Benjamin Z Ehrenpreis and Eli D Ehrenpreis

Abstract

It is widely understood that art expresses human experience to an audience. The viewer is provided with a unique form of insight when art is created by individuals depicting their own disease.

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Case Report 

Tumor Lysis Syndrome in Gastrointestinal Stromal Tumor Treated with the Oral Tyrosine Kinase Inhibitor Imatinib: A Case Report

Jeng-Nian Yuan, Anna Fen-Yau Li and Chih-Yen Chen

Abstract

Tumor lysis syndrome in hematological malignancy is more common than in solid tumors. Little literature has been published on tumor lysis syndrome in solid tumors.

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Clinical Image 

Duodenal-Type Follicular Lymphoma Mimic Follicular Hyperplasia

Yutaka Shimazu and Kazuyo Fujimura

Abstract

A 56-year-old Japanese woman with no notable medical history was admitted to our clinic because of abnormal changes in upper gastrointestinal series for regular checkup. An upper gastrointestinal endoscopy was performed. In the duodenum, white plaques resembling lymphoid hyperplasia were detected (Figure 1A, arrowheads).

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Case Report 

Codeine-Induced Pancreatitis in a Patient with Previous Cholecystectomy

Alexandra May Limmer and Zackariah Clement

Abstract

Codeine is a rare precipitant of acute pancreatitis. The hypothesised mechanism is transient codeine-induced sphincter of Oddi spasm. This case report describes an 80-year-old woman with previous cholecystectomy who developed acute pancreatitis within one hour after administration of a low dose (60 mg) codeine phosphate preparation for sialadenitis.

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Review Article 

Plant Histaminase as Bioactive Agent to Lower the Histamine Level: A Mini-Review

Mircea Alexandru Mateescu, Mireille Djatougbevi Koudoufio, Armelle Tchoumi Neree and Bruno Mondovi

Abstract

Histamine is a biogenic amine originating endogenously or exogenously from Histidine by enzymatic decarboxylation. Endogenous histamine is mostly generated by basophils and mast cells that, when activated, will release histamine that is involved in various regulatory processes but also will induce multiple allergic effects (hypotension, tachycardia, vascular risks) including anaphylactic shock and possible death.

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Review Article 

Food Safety and Climate Change: Seasonality and Emerging Food Borne Pathogens

Ahmet Koluman, Abdullah DİKİCİ, Tolga Kahraman and Gökhan Kürşad İNCİLİ

Abstract

The future consequences of climate change and its impact on food safety is still not clear due to many variations and uncertanities. It is obvious that seasonal distribution and incidence of campylobacteriosis, salmonellosis and vero-toxigenic Escherichia coli borne diseases are increasing as the environmental temperature increases.

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Research Article 

Vero-Toxigenic Escherichia Coli (VTEC): To Sum up all we know

Basak Unver Koluman and Ahmet Koluman

Abstract

Verotoxigenic Escherichia coli renamed after detection of production ability of cytotoxin which kills Vero cells, a continuous cell line derived from the kidney of the African green monkey (Chlorocebus sp). These toxins are proved to cause severe diseases in humans.

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Research Article 

Clinicopathological and Prognostic Features of Extragastrointestinal Stromal Tumors of the Omentum: A Review

Giuseppe Angelico, Saveria Spadola and Claudia Trombatore

Abstract

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal neoplasms of the digestive tract. A small percentage of GISTs form extragastrointestinal masses in the omentum, mesenteries, retroperitoneum, and undefined abdominal sites. These tumors have been labelled as "extra-gastrointestinal stromal tumors" (EGISTs). By definition, extragastrointestinal stromal tumors display no connection to the walls of the gastrointestinal tubular organs.

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Research Article 

Risk Factors for Gastrointestinal Disorders Among Iraqi Americans in Southeast Michigan, United States

Laith H Jamil, Fahad K Alobaidi, Faris Lami, Neiveen Peter and Hikmet J Jamil

Abstract

To study the prevalence of gastrointestinal disorders, understand the compliance to treatment among Iraqi Arabs and Iraqi Chaldeans, and predict risk factors for gastrointestinal disorders. 350 random samples of Iraqi Americans, who immigrated to United States from Iraq at different times reported gastrointestinal disorders. Compliance to treatment was evaluated.

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