Archives Page


Research Article 

Targeting Ability of c(RGDyK)-Functionalized Nanoparticles is Inhibited by Protein Coronas

Shanshan Zhu, Yang Liu, Changhui Wang, Kai Ye, Ping Wang, Gang Huang and Dannong He

Abstract

Nanoparticles functionalized with targeting ligands have been proposed as effective carriers for the selective delivery of diagnostic or therapeutic reagents to desired locations in the body. However protein coronas formed on the surface of such functionalized nanoparticles may affect their targeting efficiency when introduced into physiological environment.

 PDF  |   Full Text
Research Article 

Surface Density of Charged Functional Groups on Quantum Dots Determines Their Intracellular Compartmentalization and Biocompatibility

Yvonne Williams, Alyona Sukhanova, Jennifer Conroy, Bashir Mohamed, Vladimir Oleinikov, Mikhail Artemyev, Ciaran M Maguire, Igor Nabiev and Yuri Volkov

Abstract

Quantum Dots (QD) have a broad potential in the development of imaging, diagnostic and drug-delivery tools. Due to the homeostatic composition of biological systems, any charge on the surface of QD may influence penetration through the cell and organelle membranes, thus changing their cytotoxic effects.

 PDF  |   Full Text
Review Article 

Evaluation of the Potential Genotoxicity of Quantum Dots. A Review

Esref Demir and Vincent Castranova

Abstract

The Quantum Dots (QDs) are widely used in different biological and biomedical applications due to their unique optical, electronic, physicochemical properties. Different QDs recently have been used for tumour imagining, gene therapy, and drug delivery. They are developed for numerous applications.

 PDF  |   Full Text