Advances in Translational Medicine Research

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Research Article 

Enzyme Activity of 3ß-HSD and 11ß-HSD as Important Indicators of Steroid Bio-Synthesis and Inactivation in Preterm Infants

Jan De Laffolie, Lars Kastner, Michaela F Hartmann, Stefan A Wudy, Birgit Kampschulte, Bianca Grofer, Rolf-Hasso Bodeker and Matthias Heckmann

Abstract

The fetus lacks 3ß-hydroxysteroiddehydrogenase (3ß-HSD) activity until the last trimenon (requiring placental progesterone) and active cortisol concentration is regulated by synthesis through 11ß-hydroxylase and inactivation by 11ß-hydroxysteroiddehydrogenase (11ß-HSD).

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Research Article 

Cognitive Behavioral Tests May Predict Eye Affection in High-Fat Diet Induced Pre-Obese Mice: Implications for Diabetic Retinopathy

Paul F Seke Etet

Abstract

Indicators of progression to diabetic retinopathy (DR) are needed in type 2 diabetes mellitus (T2DM) obese patients. We assessed the predictive power of cognitive function indicators for eye involvement in high fat diet (HFD)-induced pre-obese mice.

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Research Article 

Inhibition of the Sonic Hedgehog Pathway by Cyclopamine or GLI1 siRNA Reduces In Vivo Tumorigenesis of Human Medulloblastoma Cells Xenotransplanted to Immunodeficient Nude Mice

Javier de la Rosa, Monica Sanchez, Monica Enguita-German, Ricardo Garcia-Lopez, Paula Schiapparelli, Mehdi H Shahi, Barbara Melendez, Juan A Rey, Miguel A Idoate and Javier S Castresana

Abstract

Medulloblastoma is an aggressive tumor; grade IV of the WHO classification that develops in the cerebellum, mostly linked to infancy and adolescence. It can be classified histologically and molecularly in different subtypes.

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